Professional and Linguistic Assessments Board (PLAB) Practice Exam

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What is the recommended treatment for eclampsia seizures?

  1. 4g of MgSO4 in 100ml 0.9% saline

  2. 5g of MgSO4 in 100ml 0.9% saline

  3. 2g of MgSO4 in 100ml 0.9% saline

  4. 5g of MgSO4 in 200ml 0.9% saline

The correct answer is: 4g of MgSO4 in 100ml 0.9% saline

The recommended treatment for eclampsia seizures primarily involves the administration of magnesium sulfate (MgSO4), which acts as a central nervous system depressant to control seizures and has neuroprotective effects. The proper dosing regimen for MgSO4 in the context of eclampsia typically includes a loading dose followed by a maintenance dose to prevent further seizures. The standard initial loading dose is indeed 4 grams of MgSO4 administered intravenously over 15 to 20 minutes, often diluted in 100 ml of 0.9% saline solution. This method allows for quick administration and facilitates effective absorption in a clinical setting. Using 4 grams of MgSO4 is well-established in guidelines due to its effectiveness in rapidly controlling eclamptic seizures while minimizing the potential for side effects. Additionally, subsequent doses can be administered for maintenance therapy after stabilization. In contrast, other dosing options may not align with the standard protocols established by medical guidelines, which emphasize the importance of using the correct dosages to optimize patient safety and therapeutic efficacy.